Side 3 av 3 Først 123
Viser søkeresultater 21 til 28 av 28
  1. #21
    Medlem siden
    Mar 2009
    Sted
    Sverige
    Alder
    74
    Meldinger
    2,323

    Lightbulb Iodine, Helicobacter Pylori, stomach cancer & evolution

    Iodine, Helicobacter Pylori, stomach cancer & evolution.
    Venturi S, Grossi L, Marra GA, Venturi A, Venturi M
    The Newsletter of the International Center for Studies and Research in Biomedicine, Luxembourg, Vol. 7, No. 2, April 2003, pp 1-7.


    The authors have hypothesized that dietary iodine (I) deficiency or excess are associated with the development of atrophic gastritis and gastric cancer (GC). They report a short review of their own work and general literature on this correlation in three fields: (1) epidemiology, where geographical and temporal correlations between territories with I-deficiency, endemic goitre and high gastric cancer-death rate are reported; (2) iodine and atrophic gastritis correlations, and (3) immunology, where the correlations between I-deficiency, immune-deficiency and gastric cancer are reported.

    Thyroid cells phylogenetically and embryologically, derived from primitive Iodine-concentrating gastric cells which, during evolution, migrated and specialized in uptake and storage of iodine, in order to adapt the organisms from Iodine-rich sea to Iodine-deficient land.

    Stomach and thyroid share an important iodide-concentrating ability and an efficient peroxidase activity, which transfers electrons from iodides to the oxygen of hydrogen peroxide and so protects the cells from peroxidations. Iodide seems to have an ancestral antioxidant function in all iodide-concentrating organisms from primitive algae to more recent vertebrates. In Italy, gastric cancer is more frequent in farmers and in Iodine-deficient populations, living in mountainous and hilly areas, than in fishermen. In the last two decades, Italian decrease of gastric cancer seems to be correlated more with the higher dietary consumption of Iodine-rich fish rather than with consumption of fruit and vegetables, which indeed has decreased in Italy.

    In conclusion, iodine deficiency or excess seem to constitute an important risk factors for atrophic gastritis and gastric cancer, both by antioxidant activity and regulating gastric trophism and by antagonizing the actions of both Helicobacter pylori and of Iodine-inhibitors, such as nitrates, thiocyanate and salt, well-known risk factors for gastric cancer.

    Read more / les mer... (Sites.google.com)
    Full Text in European EpiMarker 2003 (Researchgate.net)

  2. #22
    Medlem siden
    Mar 2009
    Sted
    Sverige
    Alder
    74
    Meldinger
    2,323

    Lightbulb Iodine, Evolution and Gastric Carcinogenesis

    Iodine, Evolution and Gastric Carcinogenesis
    Venturi S, Venturi M.
    The 2nd Esophageal & Cardiac Cancer Summit, October 18-20 2007, Beijng, China

    Lecture Presentation of 104 pages, 5 MB (PDF redirect Sites.google.com)

  3. #23
    Medlem siden
    Mar 2009
    Sted
    Sverige
    Alder
    74
    Meldinger
    2,323

    Lightbulb Clinical picture of endemic cretinism in central Apennines

    Clinical Picture of Endemic Cretinism in Central Apennines (Montefeltro)
    Donati L; Venturi S; Andreani M; Antonelli A; Gori E; Bertoni F; Pruneti CA; Berrettini S; Bruschini P; Baschieri L
    Università di Pisa, Pisa, Tuscany, Italy
    Thyroid. 10/1992; 2(4):283-290. DOI: 10.1089/thy.1992.2.283

    ABSTRACT. Endemic cretinism is still present in an endemic goiter area of the central Apennines (Montefeltro) (goiter prevalence 55%; mean urinary iodine level 39 mug/g creatinine). Clinical and biochemical features of patients with myxedematous, neurologic, and mixed cretinism were studied. Also, in this area, as in most other, neurologic cretinism is more prevalent than myxedematous and mixed forms.

    The hormonal profiles of the three types of cretinism were clearly different. Nevertheless, all myxedematous cretins had some neurologic disorders (hyperreflexia, increased muscle tone, disorder of gait, Babinski sign, hypoacusia) that were similar to those present in neurologic cretins. These findings suggest that neurologic damage is very similar in all forms of endemic cretinism, reflecting a diffuse insult to the developing fetal nervous system.

    Furthermore, these data support the hypothesis that the primary pathophysiologic event in the different types of endemic cretinism is represented by maternal and fetal hypothyroidism, while differences may be explained by the extent and duration of postnatal hypothyroidism. All the cretins were over 35 of age, suggesting a severe iodine deficiency in the past decades, and a progressive improvement of nutritional status resulted in ''silent iodine prophylaxis.''

    However, recent studies have revealed the persistence of a moderate iodine deficiency, a high prevalence of neurologic hypoacusia, and reduction of mental performance in normal schoolchildren of this area. These findings constitute strong evidence in favor of adequate iodine prophylaxis.

    Read more / Les mer... (PDF redirect Sites.google.com)
    Read more / Les mer... (Researchgate.net)




    Goitrous cretins in valleys of Apennines in the Emilia-Romagna and Tuscany regions between prof. A. Pinchera of Pisa University and prof. J.T. Dunn of Virginia University. (Photographs by Venturi, 1994)
    (Source: Site.google.com/Iodinestudies)


    Iodine Deficiency in the Population of Montefeltro, A Territory in Central Italy Inside the Regions of Emilia-Romagna, Tuscany and Marche
    Venturi S.
    International Journal of Anthropology Vol. 29 - n. 1-2 (1-12) - 2014

    Introduction. Goiter (the abnormal enlargement of the thyroid gland) is the most specific clinical marker of iodine deficiency in the human body. According to WHO, iodine deficiency is the most common cause of preventable brain damage, causing impaired cognitive development in children, and in many countries it is still a major health problem. During pregnancy, severe iodine deficiency may impair fetal development, resulting in cretinism, with irreversible mental retardation and developmental abnormalities, as well as miscarriage and stillbirth.

    This is a review of the endocrinological and neuropsychological studies conducted on the iodine deficient population of Montefeltro, a territory in central Italy, where the use of iodized table salt has only recently eradicated endemic malnutrition in its young population. However, in adults and the elderly scars still remain with some neuropsychiatric disorders and the last surviving cases of cretinism. I would also like to point out that research into the biochemical compounds of iodine is a new area of investigation and one which may provide insights into apoptosis, carcinogenesis and many cardiovascular and degenerative diseases.

    Key words: iodine deficiency, iodolipids, goiter, cretinism, brain, evolution

    Read more / Les mer... (PDF redirect Sites.google.com)

  4. #24
    Medlem siden
    Mar 2009
    Sted
    Sverige
    Alder
    74
    Meldinger
    2,323

    Lightbulb Audiological and neuropsychological development study in a sample of school...

    Audiological and neuropsychological development study in a sample of school children from a low-iodine area of the Central Apennines that is endemic for cretinism
    Donati L, Venturi S, Andreani M, Antonelli A, Gori E, Bertoni F, Pruneti CA, Berrettini S, Bruschini P, Baschieri L.
    Minerva Endocrinologica Aprile-Giugno 1989, pagina 99-103
    Article in Italian

    Abstract. Neuropsychological and audiological study in "normal" schoolchildren in an iodine deficiency area with endemic cretinism in Central Apennines.

    We have evaluated neuropsychic development in 70 normal schoolchildren in an area of severe endemic goitre and cretinism in Central Apennines (Montefeltro). In each subject we have studied auxological, psychometric and audiometric parameters, togehther with tympanogram and stapedial reflexogram. Auxological data were in the normal range, as stapedial reflexogram and tympanogram.

    On the contrary, 54,8% of the sample performed below the 25th percentile in psychometric tests (Raven test PM-47), being also 22,8% below the 5th percentile. Audiometric data showed a neurological hearing impairment in 3,1% of the children tested, as compared with 0,28% in the area of Pisa. These data point out that an impairment of central nervous system function still persist in this area of severe endemic goitre. [Min Endocr 1989;14:99-103].

    Key words: Endemic goitre, Neurological hypoacisua, Neuropsychic deficiency

    Read more / Les mer... (in Italian) (PDF redirect Sites.google.com)


    An iodine-deficient area with endemic cretinism in the Central Apennines: studies of neuropsychological development in schoolchildren.
    Donati L, Venturi S, Andreani M, et al.
    Journal of Endocrinological Investigation, 1988, 4 :11-12. nad IDD Newsletter, 1988

    Will be updated. Not found yet...

  5. #25
    Medlem siden
    Mar 2009
    Sted
    Sverige
    Alder
    74
    Meldinger
    2,323

    Lightbulb Humoral thyroid autoimmunity is not involved in the pathogenesis of myxedematous...

    Humoral thyroid autoimmunity is not involved in the pathogenesis of myxedematous endemic cretinism.
    L Chiovato, P Vitti, G Bendinelli, F Santini, E Fiore, M Tonacchera, C Mammoli, A Capaccioli, S Venturi, and E Pretell
    J Clin Endocrinol Metab. 1995 May;80(5):1509-14.
    DOI: http://dx.doi.org/10.1210/jcem.80.5.7744994

    Abstract. A role of thyroid autoimmunity in the pathogenesis of myxedematous endemic cretinism was suggested by reports indicating the presence of thyroid growth-blocking antibodies in the sera of these patients. To check this hypothesis, we searched for TSH receptor antibodies with thyroid growth-blocking or adenylate cyclase (AC)-inhibiting (TSH-blocking) activity in immunoglobulin G (IgG) from 18 euthyroid and 21 hypothyroid endemic cretins living in Italy and Peru. Among hypothyroid cretins, 12 had no palpable goiter.

    Stages I-III goiters were present in 12 of 18 euthyroid cretins. Controls included 25 euthyroid nongoitrous subjects living in the same endemic regions as cretins, and 10 normal subjects from an iodine-sufficient area. IgG from 4 selected patients with autoimmune atrophic thyroiditis and from 2 neonates with sporadic transient congenital hypothyroidism due to maternal TSH-blocking antibodies were included in the study.

    The blocking effect of the IgG was assessed in FRTL-5 cells by measuring TSH-stimulated [3H]thymidine incorporation, DNA accumulation, and AC activation. A radioreceptor assay was used to detect TSH-binding inhibiting antibodies (TBIAb). No IgG from hypothyroid endemic cretins without goiter contained TBIAb or inhibited TSH-stimulated cell growth or AC activation. The effect of IgG from hypothyroid nongoitrous cretins did not differ from that produced by IgG from hypothyroid cretins with goiter, euthyroid cretins with or without goiter, or normal controls.

    In contrast to these results, IgG from patients with autoimmune atrophic thyroiditis and from neonates with sporadic transient congenital hypothyroidism contained TBIAb that inhibited both TSH-stimulated cell growth and AC activation. In conclusion, our results indicate that, similar to other types of endemic cretinism, hypothyroid endemic cretins without goiter do not have TSH receptor antibodies able to inhibit TSH-stimulated thyroid cell growth or function.

    These observations argue against a role of humoral thyroid autoimmunity in the development of myxedematous endemic cretinism.

    Source: Press.endocrine.org

  6. #26
    Medlem siden
    Mar 2009
    Sted
    Sverige
    Alder
    74
    Meldinger
    2,323

    Lightbulb Extrathyroid Iodine Deficiency Disorders. What is the real iodine requirement?

    I disordini extra-tiroidei da carenza iodica. Qual e il real fabbisogno di iodio?
    (Extrathyroid Iodine Deficiency Disorders. What is the real iodine requirement?):


    The authors report a recent review of the most important extrathyroid iodine deficiency disorders in relation to: stomach, immune system, mammary glands, ovaries, arterial and articular system, epidermis and nervous system. All these organs concentrate about 80% of total body iodine in humans and animals, but the role of this extrathyroid iodine is not known.

    The hypothesis is that this iodine might have a specific antioxydant role, from primitive algae, which contain the highest level of iodine, and which were the first living cells to produce oxygen. So we believe that this phylogenetically ancient antioxydant role is important also in animals and humans. In fact, the thyroid gland is only a phylogenetically modern organ, which was improved from primitive Chordates to more recent Mammalia. In the references are reported different studies on the antioxydant ability of iodine in rates and in humans.

    By Venturi S, Guidi A, Venturi M. in the Journal of Italian Society of Pharmacology (Le Basi Razioneali Della Terapia), 1996; 16: 267-75. (Source: Tulane University)

  7. #27
    Medlem siden
    Mar 2009
    Sted
    Sverige
    Alder
    74
    Meldinger
    2,323

    Lightbulb Enigma of the function of iodide in primitive algae and in animal extrathyroidal...

    Enigma of the function of iodide in primitive algae and in animal extrathyroidal organs: is it an ancient antioxidant?

    Letter to the Editor


    Dear Sir,
    in relation to the functional role of inorganic iodide in metabolism of algal and animal cells, we have hypothesized, in previous (1) and recent works (2)(3) that iodide might have a (phylogenetically and evolutionistically) ancient antioxidant role in extrathyroidal iodide-concentrating cells.

    Into these cells iodide may act as an electron donor in the presence of H2O2 and peroxidase, and the remaining iodine readily iodinates the tyrosine (and more slowly, the histidine (4)(5) or some protein and lipid), and so, neutralizes its own high oxidant power (3). In fact, three billion years ago, Algae, which contain a high amount of iodine, were the first living cells to produce oxygen, toxic at that time, in terrestrial atmosphere. So, algae cells required a protective antioxidant action in which iodides might have had a specific role.

    Now this hypothesis of the antioxidant role of iodide is experimentally confirmed in Algae by a recent study carried out by Kupper et al. (6).

    We believe that this work, which convalidates our hypothesis, may constitute a fundamental experimental milestone in the study of the extrathyroidal nonhormonal action of iodine-iodide in biology and physiology of the cells.

    Several extrathyroidal organs in animals, many of which share the same gene expression of sodium-iodide symporter of thyroidal iodide-pump (7), particularly stomach mucosa and lactanting mammary gland, but also salivary glands, thymus, epidermis, choroid plexus, articular and arterial sistems, have a iodide-concentrating ability without showing any hormonal or biological action (8), and so, Algae, Porifera, Anthozoa (9) and several marine Invertebrates. In human organism extrathyroidal nonhormonal inorganic iodide is about 50-80% of the total amount of iodine and its role is not known. Besides, direct uptake of inorganic iodine by tumor shows experimentally a suppressive effect on DMBA-induced breast tumors growth in the rat (10). The antioxidant action of iodide may give a satisfactory explanation of the function of this trace-element and might be a very important knowledge for preventive purpose.

    We should point out that extrathyroidal action of iodide might be an important new area for investigation.

    REFERENCES

    1. Venturi S et al (1993) A new hypothesis: iodine and gastric cancer. European Journal of Cancer Prevention. 2 :17-23
    2. Venturi S & Venturi M (1998) Does iodine in the gastric mucosa have an ancient antioxidant role? IDD-Newsletter 14, 4 :61-2
    3. Venturi S & Venturi M (1999). Iodide, thyroid and stomach carcinogenesis: evolutionary story of a primitive antioxidant? European Journal of Endocrinology 140, 4 :371-2
    4. Li CH (1945) J Am Chem Soc 67 :1065
    5. Mayberry WE & Hockert TJ (1970). Endocrinology 86 :225..
    6. Kupper FC, Schweigert N, Ar Gall E, Legendre J-M, Vilter H & Kloareg B (1998). Iodine uptake in Laminariales involves extracellular, haloperoxidase-mediated oxidation of iodide. PLANCTA 207 :163-171
    7. Spitzweg C, Joba W, Eisenmenger W & Heufelder AE (1998). Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acid from salivary gland, mammary gland, and gastric mucosa. J Clin Endocrinol Metab 83, 5 :1746-51
    8. Venturi S, Guidi A & Venturi M (1996). I disordini extra-tiroidei da carenza iodica. Qual è il reale fabbisogno di iodio? Le Basi Razionali della Terapia 16 :267-75
    9. Roche J (1952) Biochimie comparée des scléroprotéines iodées des Anthozoaires et des Spongiaires. Experientia 8 :45-56
    10. Funahashi H, Imai T, Tanaka Y, Tobinaga J, Wada M, Morita T & al. (1996) Suppressive effect of iodine on DMBA-induced breast tumor growth in the rat. J Surg Oncol 61, 3 :209-13

  8. #28
    Medlem siden
    Mar 2009
    Sted
    Sverige
    Alder
    74
    Meldinger
    2,323

    Lightbulb Preliminary study on the relation between alimentary iodine deficiency and gastric...

    Preliminary study on the relation between alimentary iodine deficiency and gastric cancer: specific prevention prospects
    Book in Italian with summary in English
    By S. VENTURI, Pennabilli, Italy. 1-9-1985.

    This book has the following stated objective: "correlation between alimentary iodine deficiency and gastric cancer".
    The 3 methods employed are:

    1) Epidemiological Studies
    2) Study of the relation between iodine deficiency and lack of immune defense, by Skin-test
    3) Relation between gastric and Thyroid diseases
    Summary
    Competitors anions contents: Specific prevention prospects.

    See image
    Til alle norske og danske stoffskifte-pasienter, anbefaler vi boken STOP stofskiftevanviddet, skrevet av verdens ledende pasient-aktivist Janie Bowthorpe, som i 2005 grunnla nettstedet Stop The Thyroid Madness. Boken er utgitt på dansk i 2014. För alla svenska hypotyreos-patienter, rekommenderar vi samma bok, översatt till svenska med titeln Stoppa sköldkörtelskandalen (2012). Til alle gode leger, og pasienter som ønsker å lære mer av "the right stuff", anbefaler vi boken Stop The Thyroid Madness II (2014) med bidrag fra 10 leger MD. I Skandinavia, definitivt de to beste og mest nyttige bøker for hypotyreose-pasienter, for deres familier og venner, og for deres leger.

Side 3 av 3 Først 123

Lignende tråder

  1. Forskning i jod av dr. Sebastiano Venturi
    Av Mod i forumet Lavt stoffskifte og jod
    Svar: 27
    Siste melding: 01-11-15, 18:52
  2. Forskning på fibromyalgi
    Av Tily i forumet Fibromyalgi og CFS
    Svar: 1
    Siste melding: 09-06-14, 01:06
  3. Gjennombrudd i ME-forskning?
    Av Vigdis i forumet Myalgisk encefalopati (ME)
    Svar: 19
    Siste melding: 29-10-11, 10:19

Søkeord for denne tråden

Bokmerker

Regler for innlegg

  • Du kan ikke starte nye tråder
  • Du kan ikke svare på innlegg / tråder
  • Du kan ikke laste opp vedlegg
  • Du kan ikke redigere meldingene dine
  •  

Logg inn

Logg inn